Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates

被引：145

作者：

Fitzpatrick, F ^{[1
]}

Humphreys, H ^{[1
]}

O'Gara, JP ^{[1
]}

机构：

[1] Beaumont Hosp, Royal Coll Surg Ireland, Dept Clin Microbiol, Educ & Res Ctr, Dublin 9, Ireland

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 04期

关键词：

D O I：

10.1128/JCM.43.4.1973-1976.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Synthesis of a polysaccharide adhesin by icaADBC-encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica-independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.

引用

页码：1973 / 1976

页数：4

共 22 条

[1] Slime production and expression of the slime-associated antigen by staphylococcal clinical isolates
Ammendolia, MG
Di Rosa, R
Montanaro, L
Arciola, CR
Baldassarri, L
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (10) : 3235 - 3238
[2] Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections
Arciola, CR
Baldassarri, L
Montanaro, L
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (06) : 2151 - 2156
[3] Global gene expression in Staphylococcus aureus biofilms
Beenken, KE
Dunman, PM
McAleese, F
Macapagal, D
Murphy, E
Projan, SJ
Blevins, JS
Smeltzer, MS
[J]. JOURNAL OF BACTERIOLOGY, 2004, 186 (14) : 4665 - 4684
[4] Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis
Conlon, KM
Humphreys, H
O'Gara, JP
[J]. JOURNAL OF BACTERIOLOGY, 2004, 186 (18) : 6208 - 6219
[5] Conlon KM, 2002, FEMS MICROBIOL LETT, V216, P171, DOI 10.1016/S0378-1097(02)01031-5
[6] icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis
Conlon, KM
Humphreys, H
O'Gara, JP
[J]. JOURNAL OF BACTERIOLOGY, 2002, 184 (16) : 4400 - 4408
[7] The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation
Cramton, SE
Gerke, C
Schnell, NF
Nichols, WW
Götz, F
[J]. INFECTION AND IMMUNITY, 1999, 67 (10) : 5427 - 5433
[8] Anaerobic conditions induce expression of polysaccharide intercellular adhesin in Staphylococcus aureus and Staphylococcus epidermidis
Cramton, SE
Ulrich, M
Götz, F
Döring, G
[J]. INFECTION AND IMMUNITY, 2001, 69 (06) : 4079 - 4085
[9] Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis
Fitzpatrick, F
Humphreys, H
Smyth, E
Kennedy, CA
O'Gara, JP
[J]. JOURNAL OF HOSPITAL INFECTION, 2002, 52 (03) : 212 - 218
[10] The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints
Fowler, VG
Fey, PD
Reller, LB
Chamis, AL
Corey, GR
Rupp, ME
[J]. MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2001, 189 (03) : 127 - 131

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