N-[4-(1,1′-biphenyl)methyl]-4-(4-thiomorpholinylmethyl)benzenamines as non-oxazolidinone analogues of antimycobacterial U-100480.

被引：16

作者：

Artico, M

Mai, A

Sbardella, G

Massa, S

Lampis, G

Deidda, D

Pompei, R

机构：

[1] Univ Rome La Sapienza, Dipartimento Studi Farmaceut, I-00185 Rome, Italy

[2] Univ Siena, Dipartimento Farmacochim Tecnol, I-53100 Siena, Italy

[3] Univ Cagliari, Cattedra Microbiol Applicata, Fac Sci Matemat Fis & Naturali, I-09124 Cagliari, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(98)00248-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiomorpholine analogues of U-100480 with the biphenylmethyl group replacing the acetamidomethyloxazolidinone moiety have been synthesized and tested as antimycobacterial agents together with various related derivatives. Some biphenyl derivatives were endowed with high activity against Mycobacterium tuberculosis and other non-tuberculous mycobacteria. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1493 / 1498

页数：6

共 12 条

[1] OXAZOLIDINONES, A NEW CLASS OF SYNTHETIC ANTITUBERCULOSIS AGENT - INVITRO AND INVIVO ACTIVITIES OF DUP-721 AGAINST MYCOBACTERIUM-TUBERCULOSIS
ASHTEKAR, DR
COSTAPERIERA, R
SHRINIVASAN, T
IYYER, R
VISHVANATHAN, N
RITTEL, W
[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1991, 14 (06) : 465 - 471
[2] Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity
Barbachyn, MR
Hutchinson, DK
Brickner, SJ
Cynamon, MH
Kilburn, JO
Klemens, SP
Glickman, SE
Grega, KC
Hendges, SK
Toops, DS
Ford, CW
Zurenko, GE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) : 680 - 685
[3] TREATMENT OF TUBERCULOSIS AND TUBERCULOSIS INFECTION IN ADULTS AND CHILDREN
BASS, JB
FARER, LS
HOPEWELL, PC
OBRIEN, R
JACOBS, RF
RUBEN, F
SNIDER, DE
THORNTON, G
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (05) : 1359 - 1374
[4] BROWN BA, 1992, CLIN MICROBIOLOGY PR, V1
[5] DRUG-TREATMENT OF TUBERCULOSIS - 1992
DAVIDSON, PT
LE, HQ
[J]. DRUGS, 1992, 43 (05) : 651 - 673
[6] Fioravanti R, 1997, MED CHEM RES, V7, P87
[7] ANTIBACTERIALS - SYNTHESIS AND STRUCTURE ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES .1. THE B-GROUP
GREGORY, WA
BRITTELLI, DR
WANG, CLJ
WUONOLA, MA
MCRIPLEY, RJ
EUSTICE, DC
EBERLY, VS
BARTHOLOMEW, PT
SLEE, AM
FORBES, M
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) : 1673 - 1681
[8] ANTIBACTERIALS - SYNTHESIS AND STRUCTURE ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES .2. THE A GROUP
GREGORY, WA
BRITTELLI, DR
WANG, CLJ
KEZAR, HS
CARLSON, RK
PARK, CH
CORLESS, PF
MILLER, SJ
RAJAGOPALAN, P
WUONOLA, MA
MCRIPLEY, RJ
EBERLY, VS
SLEE, AM
FORBES, M
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) : 2569 - 2578
[9] Grosset J, 1990, Bull Int Union Tuberc Lung Dis, V65, P86
[10] HAWKINS JE, 1991, MANUAL CLIN MICROBIO, P1138

← 1 2 →