Human bone-marrow-derived mesenchymal stem cells: biological characteristics and potential role in therapy of degenerative diseases

被引：110

作者：

Kassem, Moustapha ^{[1
]}

Abdallah, Basem M. ^{[1
]}

机构：

[1] Odense Univ Hosp, Dept Endocrinol & Metab, DK-5000 Odense C, Denmark

来源：

CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期

关键词：

human bone; stem cells; degenerative diesease; therapy; mesenchymal stem cells;

D O I：

10.1007/s00441-007-0509-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stem cells (MSC) are a group of cells present in bone-marrow stroma and the stroma of various organs with the capacity for mesoderm-like cell differentiation into, for example, osteoblasts, adipocytes, and chondrocytes. MSC are being introduced in the clinic for the treatment of a variety of clinical conditions. The aim of this review is to provide an update regarding the biology of MSC, their identification and culture, and mechanisms controlling their proliferation and differentiation. We also review the current status of their clinical use. Areas in which research is needed to enhance the clinical use of MSC are emphasized.

引用

页码：157 / 163

页数：7

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