No background concentrations of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in blood of rats

被引：17

作者：

Kessler, W

Phokha, W

Csanády, GA

Filser, JG

机构：

[1] GSF Forschungszentrum Umwelt & Gesundheit, Inst Toxikol, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Inst Toxikol & Umwelthyg, Munich, Germany

来源：

ARCHIVES OF TOXICOLOGY | 2001年 / 75卷 / 01期

关键词：

di(2-ethylhexyl) phthalate; mono(2-ethylhexyl) phthalate; rat; blood;

D O I：

10.1007/s002040000198

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

We measured the background levels of di(2-ethylhexyl) phthalate (DEHP) and its hydrolytic metabolite mono(2-ethylhexyl) phthalate (MEHP) in blood from naive female Sprague-Dawley rats and in de-ionized charcoal-purified water using an analytical procedure that is based on sample treatment with acetonitrile, n-hexane extraction and analysis by gas chromatography. In blood, blank values of 91.3 +/- 34.7 mug DEHP/1 (n=31) and 30.1 +/- 13.1 mug MEHP/1 (n=20) were obtained, and in water, values of 91.6 +/- 44.2 mug DEHP/1 (n = 26) and 26.7 +/- 10.4 mug MEHP/1 (n = 15) were found. Since there is no difference between the background valves obtained from blood of naive rats and water, we conclude that DEHP and MEHP result from contamination during the analytical procedure.

引用

收藏

页码：62 / 64

页数：3

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