A radical cyclization approach to isoindolobenzazepines. Synthesis of lennoxamine

被引：73

作者：

Rodriguez, G

Cid, MM

Saa, C

Castedo, L

Dominguez, D

机构：

[1] UNIV SANTIAGO,FAC QUIM,DEPT QUIM ORGAN,E-15706 SANTIAGO,SPAIN

[2] CSIC,SECC ALCALOIDES,E-15706 SANTIAGO,SPAIN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 08期

关键词：

D O I：

10.1021/jo952113k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alkaloid lennoxamine (1) was synthesized by transannular cyclization of a 10-membered lactam obtained by intramolecular addition of an aryl radical to a (trimethylsilyl)acetylene. The isoindolo-[1,2-b][3]benzazepine skeleton present in lennoxamine was also obtained by means of regioselective 7-endo-trig radical cyclization of methylenephthalimidines.

引用

页码：2780 / 2782

页数：3

共 18 条

[1]

BERNHARD HO, 1971, TETRAHEDRON LETT, P4867

[2]

DORN CR, 1984, J ORG CHEM, V49, P2642

[3] SYNTHESIS OF BERBERASTINE [J].