Multiple sclerosis: a polygenic disease involving epistatic interactions, germline rearrangements and environmental effects

被引：22

作者：

Karpuj, MV

Steinman, L ^{[1
]}

Oksenberg, JR

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[2] Stanford Univ, Dept Neurol Sci, Stanford, CA 943053 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

NEUROGENETICS | 1997年 / 1卷 / 01期

关键词：

multiple sclerosis; autoimmunity; epistasis; genetic rearrangement; linkage;

D O I：

10.1007/s100480050003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several regions of the human genome are associated with susceptibility to multiple sclerosis (MS). We review studies of linkage of MS to germline genes using microsatellites. A modest effect on susceptibility was seen with markers in the vicinity of 6p21 (HLA) and 17q22. The influence of epistatic interactions between these genes is considered. The impact of genetic rearrangements of certain germline genes on susceptibility to MS is described. Analysis of TCR gene rearrangements has established some of the target antigens of the immune response in MS. Environmental influences on MS are described with particular attention given to how microbes might trigger demyelinating disease.

引用

页码：21 / 28

页数：8

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