Syndecans - New kids on the signaling block

被引：370

作者：

Tkachenko, E

Rhodes, JM

Simons, M

机构：

[1] Dartmouth Coll Sch Med, Angiogenesis Res Ctr, Cardiol Sect, Lebanon, NH USA

[2] Dartmouth Coll Sch Med, Dept Med, Lebanon, NH USA

[3] Dartmouth Coll Sch Med, Dept Pharmacol & Toxicol, Lebanon, NH USA

来源：

CIRCULATION RESEARCH | 2005年 / 96卷 / 05期

关键词：

proteoglycan; angiogenesis; signal transduction; cytoskeleton; migration;

D O I：

10.1161/01.RES.0000159708.71142.c8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies have demonstrated the essential role of syndecans in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. In this review, we focus on new advances in our understanding of syndecan-mediated cell signaling.

引用

页码：488 / 500

页数：13

共 141 条

[1] QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling [J].