Liquid-liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review

被引：180

作者：

Elbert, Donald L. ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Washington Univ, Ctr Mat Innovat, St Louis, MO 63130 USA

来源：

ACTA BIOMATERIALIA | 2011年 / 7卷 / 01期

关键词：

Suspension polymerization; Emulsion polymerization; Precipitation polymerization; Phase inversion; Colloid; DEGRADABLE POLYMERIC CARRIER; OSTEOGENIC CELL-POPULATIONS; MARROW STROMAL OSTEOBLASTS; INVERSE EMULSION POLYMERIZATION; BIODEGRADABLE DEXTRAN NANOGELS; MOLECULAR-SIZE DISTRIBUTION; HYBRID ARTIFICIAL PANCREAS; BASE COACERVATION SYSTEMS; SOLUBLE NONIONIC POLYMERS; PHASE-SEPARATION;

D O I：

10.1016/j.actbio.2010.07.028

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Macroporous hydrogels may have direct applications in regenerative medicine as scaffolds to support tissue formation. Hydrogel microspheres may be used as drug-delivery vehicles or as building blocks to assemble modular scaffolds. A variety of techniques exist to produce macroporous hydrogels and hydrogel microspheres. A subset of these relies on liquid-liquid two-phase systems. Within this subset, vastly different types of polymerization processes are found. In this review, the history, terminology and classification of liquid-liquid two-phase polymerization and crosslinking are described. Instructive examples of hydrogel microsphere and macroporous scaffold formation by precipitation/dispersion, emulsion and suspension polymerizations are used to illustrate the nature of these processes. The role of the kinetics of phase separation in determining the morphology of scaffolds and microspheres is also delineated. Brief descriptions of miniemulsion, microemulsion polymerization and ionotropic gelation are also included. (c) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：31 / 56

页数：26

共 255 条

[1]

Albertsson P.A., 1986, PARTITION CELL PARTI

[2]

Definitions of terms relating to the structure and processing of sols, gels, networks, and inorganic-organic hybrid materials (IUPAC Recommendations 2007) [J].

Aleman, J. ;

Chadwick, A. V. ;

He, J. ;

Hess, M. ;

Horie, K. ;

Jones, R. G. ;

Kratochvil, P. ;

Meisel, I. ;

Mita, I. ;

Moad, G. ;

Penczek, S. ;

Stepto, R. F. T. .

PURE AND APPLIED CHEMISTRY, 2007, 79 (10) :1801-1827

[3]

[Anonymous], 2003, Molecular Driving Forces: Statistical Thermodynamics in Chemistry Biology

[4]

Design and production of nanoparticles formulated from nano-emulsion templates-A review [J].

Anton, Nicolas ;

Benoit, Jean-Pierre ;

Saulnier, Patrick .

Journal of Controlled Release, 2008, 128 (03) :185-199

[5]

The universality of low-energy nano-emulsification [J].

Anton, Nicolas ;

Vandamme, Thierry F. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 377 (1-2) :142-147

[6]

SUSPENSION, DISPERSION, AND INTERFACIAL POLYCONDENSATION - A METHODOLOGICAL SURVEY [J].

ARSHADY, R ;

GEORGE, MH .

POLYMER ENGINEERING AND SCIENCE, 1993, 33 (14) :865-876

[7]

SUSPENSION, EMULSION, AND DISPERSION POLYMERIZATION - A METHODOLOGICAL SURVEY [J].

ARSHADY, R .

COLLOID AND POLYMER SCIENCE, 1992, 270 (08) :717-732

[8]

MICROSPHERES AND MICROCAPSULES, A SURVEY OF MANUFACTURING TECHNIQUES .2. COACERVATION [J].

ARSHADY, R .

POLYMER ENGINEERING AND SCIENCE, 1990, 30 (15) :905-914

[9]

LARGE-SCALE MICROSEGREGATION IN POLYACRYLAMIDE GELS (SPINODAL GELS) [J].

ASNAGHI, D ;

GIGLIO, M ;

BOSSI, A ;

RIGHETTI, PG .

JOURNAL OF CHEMICAL PHYSICS, 1995, 102 (24) :9736-9742

[10]

Micro total analysis systems. 2. Analytical standard operations and applications [J].

Auroux, PA ;

Iossifidis, D ;

Reyes, DR ;

Manz, A .

ANALYTICAL CHEMISTRY, 2002, 74 (12) :2637-2652

← 1 2 3 4 5 6 7 8 9 10 →