The MCM complex: (just) a replicative helicase?

被引：51

作者：

Costa, Alessandro ^{[1
]}

Onesti, Silvia ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

ATPase associated with various cellular activities (AAA plus ); DNA replication; helicase; initiator; minichromosome maintenance 2-7 (MCM2-MCM7);

D O I：

10.1042/BST0360136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MCM2-MCM7 (minichromosome maintenance 2-7) complex is involved both in the initiation and the elongation step of eukaryotic DNA replication and is believed to be the replicative helicase. Whereas the mechanism of DNA unwinding at the replication fork has been extensively investigated, the role of the MCM2-MCM7 complex during initiation has not yet been characterized by biochemical studies. Here we summarize the in vivo evidence which supports a role for the MCM complex in origin melting. in addition, we present an overview of the mechanism of action of a number of AAA+ (ATPase associated with various cellular activities) initiators and hexameric helicases, which can be used in turn as models for the steps of recognition, duplex melting, loading and nucleic acid translocation of the MCM helicase.

引用

页码：136 / 140

页数：5

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