Evolution of silicone therapy and mechanism of action in scar management

被引:256
作者
Mustoe, Thomas A. [1 ]
机构
[1] Northwestern Univ, Sch Med, Div Plast Surg, Chicago, IL 60611 USA
关键词
hydration; hypertrophic scar; keloid; occlusion; silicone gel; silicone gel sheeting;
D O I
10.1007/s00266-007-9030-9
中图分类号
R61 [外科手术学];
学科分类号
摘要
Silicone-based products are widely used in the management of hypertrophic scarring and keloids. This review discusses the range of products available and the clinical evidence of their efficacy in preventing excessive scarring and improving established scars. Silicone gel sheeting has been used successfully for more than 20 years in scar management. A new formulation of silicone gel applied from a tube forms a thin flexible sheet over the newly epithelialized wound or more mature scar. Results from clinical trials and clinical experience suggest that silicone gel is equivalent in efficacy to traditional silicone gel sheeting but easier to use. The mechanism of action of silicone therapy has not been completely determined but is likely to involve occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts.
引用
收藏
页码:82 / 92
页数:11
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