Current practices of donor pancreas allocation in the UK: future implications for pancreas and islet transplantation

被引:15
作者
Ridgway, DM [1 ]
White, SA [1 ]
Kimber, RM [1 ]
Nicholson, ML [1 ]
机构
[1] Univ Leicester, Div Transplantat, Leicester Gen Hosp, Leicester, Leics, England
关键词
islet transplantation; organ donation; pancreas transplantation;
D O I
10.1111/j.1432-2277.2005.00144.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
Recent refinements in technique mean islet cell transplantation offers the chance of a cure to an increasing patient cohort with diabetes. Such developments Put pressure upon the scarce resource of donor organs, with potential competition between the modalities of cellular and solid organ transplantation. This questionnaire based study examines current patterns of donor pancreas procurement and use. Reasons for non procurement are studied together with the attitudes of transplant professionals to pancreas allocation. The minority of potentially useful pancreata are currently made available to either whole pancreas or islet transplant programs. Whilst professionals appreciate the role of each modality, there is a need to define criteria for pancreas allocation to avoid under use of donor organs.
引用
收藏
页码:828 / 834
页数:7
相关论文
共 31 条
[1]   HUMAN ISLET ISOLATION IN 104 CONSECUTIVE CASES - FACTORS AFFECTING ISOLATION SUCCESS [J].
BENHAMOU, PY ;
WATT, PC ;
MULLEN, Y ;
INGLES, S ;
WATANABE, Y ;
NOMURA, Y ;
HOBER, C ;
MIYAMOTO, M ;
KENMOCHI, T ;
PASSARO, EP ;
ZINNER, MJ ;
BRUNICARDI, FC .
TRANSPLANTATION, 1994, 57 (12) :1804-1810
[2]  
*CDBI, 2001, J INT BIOETHIQUE, V12, P47
[3]   MULTIVARIATE-ANALYSIS OF DONOR RISK-FACTORS FOR PANCREAS ALLOGRAFT FAILURE AFTER SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION [J].
DOUZDJIAN, V ;
GUGLIUZZA, KG ;
FISH, JC .
SURGERY, 1995, 118 (01) :73-81
[4]   Reversal of lesions of diabetic nephropathy after pancreas transplantation [J].
Fioretto, P ;
Steffes, MW ;
Sutherland, DER ;
Goetz, FC ;
Mauer, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (02) :69-75
[5]   DONOR HYPERGLYCEMIA AS A MINOR RISK FACTOR AND IMMUNOLOGICAL VARIABLES AS MAJOR RISK-FACTORS FOR PANCREAS ALLOGRAFT LOSS IN A MULTIVARIATE-ANALYSIS OF A SINGLE INSTITUTIONS EXPERIENCE [J].
GORES, PF ;
GILLINGHAM, KJ ;
DUNN, DL ;
MOUDRYMUNNS, KC ;
NAJARIAN, JS ;
SUTHERLAND, DER .
ANNALS OF SURGERY, 1992, 215 (03) :217-230
[6]  
HERING BJ, 2001, ACTA CHIR AUST S174, V33, P33
[7]   Strategies to expand the donor pool for pancreas transplantation [J].
Kapur, S ;
Bonham, CA ;
Dodson, SF ;
Dvorchik, I ;
Corry, RJ .
TRANSPLANTATION, 1999, 67 (02) :284-290
[8]   Influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients within the swiss-french GRAGIL network [J].
Kessler, L ;
Bucher, P ;
Milliat-Guittard, L ;
Benhamou, PY ;
Berney, T ;
Penfornis, A ;
Badet, L ;
Thivolet, C ;
Bayle, F ;
Oberholzer, J ;
Renoult, E ;
Brun, JM ;
Rifle, G ;
Atlan, C ;
Colin, C ;
Morel, P .
TRANSPLANTATION, 2004, 77 (08) :1301-1304
[9]  
KNETEMAN NM, 1992, DIABETES NUTR METAB, V5, P33
[10]   Risk factors for intra-abdominal infection after pancreas transplantation [J].
Knight, RJ ;
Bodian, C ;
Rodriguez-Laiz, G ;
Guy, SR ;
Fishbein, TM .
AMERICAN JOURNAL OF SURGERY, 2000, 179 (02) :99-102