Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate

被引:83
作者
Dopazo, J
Mendoza, A
Herrero, J
Caldara, F
Humbert, Y
Friedl, L
Guerrier, M
Grand-Schenk, E
Gandin, C
De Franceso, M
Polissi, A
Buell, G
Feger, G
García, E
Peitsch, M
García-Bustos, JF
机构
[1] GlaxoSmithKline SpA, Med Res Ctr, Dept Microbiol, I-37100 Verona, Italy
[2] Glaxo Wellcome Res & Dev SA, Geneva Biomed Res Inst, Geneva, Switzerland
[3] CSIC, Ctr Invest Biol, Dept Mol Microbiol, E-28006 Madrid, Spain
[4] GlaxoSmithKline, Res Dept, Tres Cantos 28760, Spain
来源
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE | 2001年 / 7卷 / 02期
关键词
D O I
10.1089/10766290152044995
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often empresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
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页码:99 / 125
页数:27
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