RETRACTED: Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia (Retracted Article)

被引：1301

作者：

Zhang, Huafeng ^{[1
,2
]}

Bosch-Marce, Marta ^{[1
,2
]}

Shimoda, Larissa A. ^{[3
]}

Tan, Yee Sun ^{[1
,2
]}

Baek, Jin Hyen ^{[1
,2
]}

Wesley, Jacob B. ^{[1
,2
]}

Gonzalez, Frank J. ^{[4
]}

Semenza, Gregg L. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[4] NCI, Lab Metab, Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 16期

关键词：

D O I：

10.1074/jbc.M800102200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.

引用

页码：10892 / 10903

页数：12

共 45 条

[1] HIF-1 regulation of chondrocyte apoptosis - Induction of the autophagic pathway [J].

Bohensky, Jolene ;

Shapiro, Irving M. ;

Leshinsky, Serge ;

Terkhorn, Shawn P. ;

Adams, Christopher S. ;

Srinivas, Vickram .

AUTOPHAGY, 2007, 3 (03) :207-214

[2] Oxygen, a source of life and stress [J].

Brahimi-Horn, M. Christiane ;

Pouyssegur, Jacques .

FEBS LETTERS, 2007, 581 (19) :3582-3591

[3] Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia [J].

Bruick, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9082-9087

[4] Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia -: A mechanism of O2 sensing [J].

Chandel, NS ;

McClintock, DS ;

Feliciano, CE ;

Wood, TM ;

Melendez, JA ;

Rodriguez, AM ;

Schumacker, PT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25130-25138

[5] Dioxygenases as O2-dependent regulators of the hypoxic response pathway [J].

Dann, CE ;

Bruick, RK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (01) :639-647

[6]

DECKER RS, 1980, AM J PATHOL, V98, P425

[7] FUNCTIONS OF LYSOSOMES [J].

DEDUVE, C ;

WATTIAUX, R .

ANNUAL REVIEW OF PHYSIOLOGY, 1966, 28 :435-+

[8] Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition -: The role of HIF-1α, HIF-2α, and other pathways [J].

Elvidge, Gareth P. ;

Glenny, Louisa ;

Appelhoff, Rebecca J. ;

Ratcliffe, Peter J. ;

Ragoussis, Jiannis ;

Gleadle, Jonathan M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (22) :15215-15226

[9]

Feldser D, 1999, CANCER RES, V59, P3915

[10]

Forsythe JA, 1996, MOL CELL BIOL, V16, P4604

← 1 2 3 4 5 →