Myogenic satellite cells: physiology to molecular biology

被引:1168
作者
Hawke, TJ
Garry, DJ
机构
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
关键词
skeletal muscle; stem cells; regeneration; aging; transgenic models;
D O I
10.1152/jappl.2001.91.2.534
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Adult skeletal muscle has a remarkable ability to regenerate following myotrauma. Because adult myofibers are terminally differentiated, the regeneration of skeletal muscle is largely dependent on a small population of resident cells termed satellite cells. Although this population of cells was identified 40 years ago, little is known regarding the molecular phenotype or regulation of the satellite cell. The use of cell culture techniques and transgenic animal models has improved our understanding of this unique cell population; however, the capacity and potential of these cells remain ill-defined. This review will highlight the origin and unique markers of the satellite cell population, the regulation by growth factors, and the response to physiological and pathological stimuli. We conclude by highlighting the potential therapeutic uses of satellite cells and identifying future research goals for the study of satellite cell biology.
引用
收藏
页码:534 / 551
页数:18
相关论文
共 219 条
[1]   Time course of changes in markers of myogenesis in overloaded rat skeletal muscles [J].
Adams, GR ;
Haddad, F ;
Baldwin, KM .
JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (05) :1705-1712
[2]  
ALI MA, 1981, ACTA ANAT, V110, P287
[3]   REGULATION OF SKELETAL-MUSCLE SATELLITE CELL-PROLIFERATION AND DIFFERENTIATION BY TRANSFORMING GROWTH FACTOR-BETA, INSULIN-LIKE GROWTH FACTOR-I, AND FIBROBLAST GROWTH-FACTOR [J].
ALLEN, RE ;
BOXHORN, LK .
JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (02) :311-315
[4]   HEPATOCYTE GROWTH-FACTOR ACTIVATES QUIESCENT SKELETAL-MUSCLE SATELLITE CELLS IN-VITRO [J].
ALLEN, RE ;
SHEEHAN, SM ;
TAYLOR, RG ;
KENDALL, TL ;
RICE, GM .
JOURNAL OF CELLULAR PHYSIOLOGY, 1995, 165 (02) :307-312
[5]  
Andermarcher E, 1996, DEV GENET, V18, P254, DOI 10.1002/(SICI)1520-6408(1996)18:3<254::AID-DVG6>3.0.CO
[6]  
2-8
[7]   A role for nitric oxide in muscle repair: Nitric oxide-mediated activation of muscle satellite cells [J].
Anderson, JE .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (05) :1859-1874
[8]   STIMULATION OF MYOBLAST PROLIFERATION IN CULTURE BY LEUKEMIA INHIBITORY FACTOR AND OTHER CYTOKINES [J].
AUSTIN, L ;
BURGESS, AW .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1991, 101 (02) :193-197
[9]   Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function [J].
Barton-Davis, ER ;
Shoturma, DI ;
Musaro, A ;
Rosenthal, N ;
Sweeney, HL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15603-15607
[10]   Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells [J].
Beauchamp, JR ;
Heslop, L ;
Yu, DSW ;
Tajbakhsh, S ;
Kelly, RG ;
Wernig, A ;
Buckingham, ME ;
Partridge, TA ;
Zammit, PS .
JOURNAL OF CELL BIOLOGY, 2000, 151 (06) :1221-1233