Baculoviral vectors for gene delivery: A review

被引：114

作者：

Hu, Yu-Chen ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 300, Taiwan

来源：

CURRENT GENE THERAPY | 2008年 / 8卷 / 01期

关键词：

D O I：

10.2174/156652308783688509

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Baculovirus has emerged as a novel vector for in vivo and in vitro gene delivery. In addition, the applications of baculovirus-mediated gene transfer have been explosively expanded to drug screening, eucaryotic gene display, cancer therapy and tissue engineering, etc. The capability of baculovirus viral envelope for protein/peptide display also renders itself a potential vaccine delivery platform. This paper reviews the history, factors influencing baculovirus-mediated gene delivery and emerging in vitro, in vivo and ex vivo applications. Efforts aimed at overcoming current existing bottlenecks and recent progresses in addressing the safety concerns are particularly emphasized.

引用

页码：54 / 65

页数：12

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