Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas

被引：43

作者：

Falchetti, ML

Pallini, R

Larocca, LM

Verna, R

D'Ambrosio, E

机构：

[1] CNR, Ist Med Sperimentale, I-00137 Rome, Italy

[2] Univ Cattolica, Ist Neurochirurg, Rome, Italy

[3] Univ Cattolica, Ist Anat Patol, Rome, Italy

[4] Univ La Sapienza, Dipartimento Med Sperimentale, Rome, Italy

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1999年 / 52卷 / 03期

关键词：

intracranial tumours; telomerase; TRAP;

D O I：

10.1136/jcp.52.3.234

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aim - To evaluate the diagnostic value of telomerase expression in intracranial tumours. Methods - 98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with tl-le histological diagnosis and the proliferation index. Results - A high degree of positivity for telomerase activity was found in gliablastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas. Conclusions - The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.

引用

页码：234 / 236

页数：3

共 10 条

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Avilion AA, 1996, CANCER RES, V56, P645

[2] Increased sensitivity and reproducibility of TRAP assay by avoiding direct primers interaction [J].