Multiple chromatographic fingerprinting and its application to the quality control of herbal medicines

被引:184
作者
Fan, XH
Cheng, YY [1 ]
Ye, ZL
Lin, RC
Qian, ZZ
机构
[1] Zhejiang Univ, Pharmaceut Informat Inst, Coll Pharmaceut Sci, Hangzhou 310027, Peoples R China
[2] Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
[3] Comm Chinese Pharmacopoeia, Beijing 100061, Peoples R China
基金
中国国家自然科学基金;
关键词
multiple chromatographic fingerprinting; data fusion; quality control of herbal medicines; Danshen dropping pill; Salvia miltiorrhiza Bunge; Panax notoginseng;
D O I
10.1016/j.aca.2005.09.037
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Recently, chromatographic fingerprinting has become one of the most powerful approaches to quality control of herbal medicines. However, the performance of reported chromatographic fingerprinting constructed by single chromatogram sometimes turns out to be inadequate for complex herbal medicines, such as multi-herb botanical drug products. In this study, multiple chromatographic fingerprinting, which consists of more than one chromatographic fingerprint and represents the whole characteristics of chemical constitutions of the complex medicine, is proposed as a potential strategy in this complicated case. As a typical example, a binary chromatographic fingerprinting of "Danshen Dropping Pill" (DSDP), the best-sold traditional Chinese medicine in China, was developed. First, two HPLC fingerprints that, respectively, represent chemical characteristics of depsides and saponins of DSDP were developed, which were used to construct binary chromatographic fingerprints of DSDP. Moreover, the authentication and validation of the binary fingerprints were performed. Then, a data-level information fusion method was employed to capture the chemical information encoded in two chromatographic fingerprints. Based on the fusion results, the lot-to-lot consistency and frauds can be determined either using similarity measure or by chemometrics approach. The application of binary chromatographic fingerprinting to consistency assessment and frauds detection of DSDP clearly demonstrated that the proposed method was a powerful approach to quality control of complex herbal medicines. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:217 / 224
页数:8
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