Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology

被引：199

作者：

Brandes, Alba A. ^{[1
]}

Tosoni, Alicia ^{[1
]}

Spagnolli, Federica ^{[2
]}

Frezza, Giarnpiero ^{[2
]}

Leonardi, Marco ^{[3
]}

Calbucci, Fabio ^{[4
]}

Franceschi, Enrico ^{[1
]}

机构：

[1] AUSL Bologna, Bellaria Maggiore Hosp, Dept Med Oncol, Bologna, Italy

[2] AUSL Bologna, Bellaria Maggiore Hosp, Dept Radiotherapy, Bologna, Italy

[3] AUSL Bologna, Bellaria Maggiore Hosp, Dept Neuroradiol, Bologna, Italy

[4] AUSL Bologna, Bellaria Maggiore Hosp, Dept Neurosurg, Bologna, Italy

来源：

NEURO-ONCOLOGY | 2008年 / 10卷 / 03期

关键词：

chemotherapy; glioma; pseudoprogression; radionecrosis; radiotherapy;

D O I：

10.1215/15228517-2008-008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although radionecrosis has been exhaustively described in depth in the neurooncological literature, its diagnosis is still a challenging issue because its radiological pattern is frequently indistinguishable from that of tumor recurrence. This review discusses the causes of radionecrosis and the potential effect of adjuvant chemotherapy concomitant with radiotherapy on its rate and onset. The potential pitfalls in clinical studies attempting to make a differential diagnosis between radionecrosis and disease progression are also discussed.

引用

页码：361 / 367

页数：7

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