Prevalence of GB virus type C hepatitis G virus RNA and of anti-E2 in individuals at high or low risk for blood-borne or sexually transmitted viruses:: evidence of sexual and parenteral transmission

被引:58
作者
Lefrère, JJ
Roudot-Thoraval, F
Morand-Joubert, L
Brossard, Y
Parnet-Mathieu, F
Mariotti, M
Agis, F
Rouet, G
Lerable, J
Lefèvre, G
Girot, R
Loiseau, P
机构
[1] Inst Natl Transfus Sanguine, F-75012 Paris, France
[2] Hop St Antoine, Virol Lab, F-75571 Paris, France
[3] Hop St Antoine, Ctr Hemobiol Perinatale, F-75571 Paris, France
[4] Hop Tenon, Biochim Lab, F-75970 Paris, France
[5] Hop Tenon, Hematol Lab, F-75970 Paris, France
[6] Hop St Louis, Assistance Publ Hop Paris, Etab Transfus Sanguine, Paris, France
[7] Hop Henri Mondor, Serv Sante Publ, F-94010 Creteil, France
[8] Etab Transfus Sanguine, Pointe A Pitre, Guadeloupe, France
关键词
D O I
10.1046/j.1537-2995.1999.39199116899.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: The first epidemiologic evidence of GB virus type C (GBV-C)/hepatitis G virus (HGV) infection showed a high prevalence of asymptomatic carriers in blood donors and in populations at risk for blood-borne viruses. However, by using only viral RNA polymerase chain reaction, those studies underestimated the true spread of GBV-C/HGV infection. The combined detection of GBV-C/HGV RNA and of anti-E2 (which reflects recovery from infection) is necessary to define accurately the prevalence of GBV-C/HGV. STUDY DESIGN AND METHODS: The presence of both anti-E2 and GBV-C/HGV RNA was searched for in 1438 serum samples collected from various groups of individuals at low or high risk for blood-borne or sexually transmitted viruses (blood donors, organ donors, unselected pregnant women, immunocompetent or immunodepressed multiply transfused patients, HIV-positive or HIV-negative homosexual men, intravenous drug addicts). RESULTS: The presence of GBV-C/HGV RNA and/or anti-E2 (exposure to GBV-C/HGV) was frequent in populations at risk for blood-borne or sexually transmitted viruses. GBV-C/HGV appeared also to be sexually transmitted, with transmission from male to female more efficient than vice versa. A particularly elevated level of exposure to GBV-C/HGV was observed in homosexual men. In immunocompetent individuals, the prevalence of anti-E2 was about twice that of GBV-C/HGV RNA, which suggests the frequency of recovery from GBV-C/HGV infection. Most of the GBV-C/HGV RNA-positive individuals had no biochemical evidence of liver damage. CONCLUSIONS: GBV-C/HGV is frequent in populations at risk for blood-borne or sexually transmitted viruses. GBV-C/HGV is not a hepatitis virus, and it seems appropriate to rename it.
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页码:83 / 94
页数:12
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