Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

被引：347

作者：

Kirn, D ^{[1
]}

Martuza, RL

Zwiebel, J

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Viral & Genet Therapy Programme, Sch Med, London, England

[2] Hammersmith Hosp, Imperial Canc Res Fund, London, England

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Massachusetts Gen Hosp, Boston, MA 02114 USA

[5] NCI, Div Canc Treatment, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 07期

关键词：

D O I：

10.1038/89901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underlying biological principles and current status of the field, outlines approaches for improving clinical effectiveness and discusses the unique safety and regulatory issues surrounding viral therapies.

引用

页码：781 / 787

页数：7

共 79 条

[1]

ALEMANY N, 2000, CLIN CANCER RES, V6, P3395

[2]

[Anonymous], P AM SOC CLIN ONCOLO

[3] ADENOVIRUS PROTEINS FROM BOTH E1B READING FRAMES ARE REQUIRED FOR TRANSFORMATION OF RODENT CELLS BY VIRAL-INFECTION AND DNA TRANSFECTION [J].

BARKER, DD ;

BERK, AJ .

VIROLOGY, 1987, 156 (01) :107-121

[4] A 15-year follow-up of AJCC stage III malignant melanoma patients treated postsurgically with Newcastle disease virus (NDV) oncolysate and determination of alterations in the CD8 T cell repertoire [J].

Batliwalla, FM ;

Bateman, BA ;

Serrano, D ;

Murray, D ;

Macphail, S ;

Maino, VC ;

Ansel, JC ;

Gregersen, PK ;

Armstrong, CA .

MOLECULAR MEDICINE, 1998, 4 (12) :783-794

[5] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].

Bischoff, JR ;

Kim, DH ;

Williams, A ;

Heise, C ;

Horn, S ;

Muna, M ;

Ng, L ;

Nye, JA ;

SampsonJohannes, A ;

Fattaey, A ;

McCormick, F .

SCIENCE, 1996, 274 (5286) :373-376

[6]

BRYSON JS, 1988, CANCER IMMUNOL IMMUN, V26, P132

[7]

CASSEL WA, 1983, CANCER, V52, P856, DOI 10.1002/1097-0142(19830901)52:5<856::AID-CNCR2820520519>3.0.CO

[8]

2-4

[9]

Chalavi A, 1999, NEOPLASIA, V1, P162

[10] Reovirus therapy of tumors with activated Ras pathway [J].

Coffey, MC ;

Strong, JE ;

Forsyth, PA ;

Lee, PWK .

SCIENCE, 1998, 282 (5392) :1332-1334

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