Increasing severity of cardiac autonomic neuropathy is associated with increasing prevalence of nephropathy, retinopathy, and peripheral neuropathy in Turkish type 2 diabetics

被引:14
作者
Bilal, Nevzat [1 ]
Erdogan, Mehmet [1 ]
Oezbek, Mustafa [1 ]
Cetinkalp, Sevki [1 ]
Karadeniz, Muammer [1 ]
Oezgen, Ahmet Gokhan [1 ]
Saygili, Fusun [1 ]
Yilmaz, Candeger [1 ]
Tuezuen, Mehmet [1 ]
Kabalak, Taylan [1 ]
机构
[1] Ege Univ, Sch Med, Izmir, Turkey
关键词
type; 2; diabetes; cardiac autonomic neuropathy; microvascular complications;
D O I
10.1016/j.jdiacomp.2006.12.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Cardiac autonomic neuropathy (CAN) is the most frequent and clinically important form of diabetic autonomic neuropathy. CAN is associated with increased frequency of other microvascular complications of diabetes mellitus (DM). In this study, we evaluated the prevalence diabetic nephropathy, retinopathy, and peripheral neuropathy, and measured gastric emptying time and bladder emptying time in type 2 diabetic patients with varying degrees of CAN. Patients and Methods: Fifty-three patients with DM complicated by CAN (30 women and 23 men; mean age, 58.8 +/- 9.15 years; duration of diabetes, 13.9 +/- 7.7 years) were included in this study. The patients were grouped according to the degree of CAN as early, definite, and severe CAN. Results: There were significant differences regarding the prevalence of nephropathy, retinopathy, and peripheral neuropathy diagnosed by EMG among those groups (P.05). However, there was no significant difference regarding the prevalence of peripheral neuropathy diagnosed by neurological examination (P>.05), and scintigraphic measurements of gastric and bladder emptying time were comparable among the groups (P>.05). Conclusion: The prevalence of other diabetic microvascular complications increase as the severity of CAN increases in patients with type 2 DM. This study emphasizes the need for an early screening for peripheral neuropathy, retinopathy, and nephropathy in type 2 diabetic patients with CAN, especially with severe involvement. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:181 / 185
页数:5
相关论文
共 17 条
[1]   Simultaneous measurement of gastric emptying of a solid meal by ultrasound and by scintigraphy [J].
Benini, L ;
Sembenini, C ;
Heading, RC ;
Giorgetti, PG ;
Montemezzi, S ;
Zamboni, M ;
Di Benedetto, P ;
Brighenti, F ;
Vantini, I .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (10) :2861-2865
[2]   Pathophysiology of diabetic gastroparesis [J].
Enck, P ;
Frieling, T .
DIABETES, 1997, 46 :S77-S81
[3]   DIAGNOSIS AND MANAGEMENT OF DIABETIC AUTONOMIC NEUROPATHY [J].
EWING, DJ ;
CLARKE, BF .
BRITISH MEDICAL JOURNAL, 1982, 285 (6346) :916-918
[4]   ASSESSMENT OF CARDIOVASCULAR EFFECTS IN DIABETIC AUTONOMIC NEUROPATHY AND PROGNOSTIC IMPLICATIONS [J].
EWING, DJ ;
CAMPBELL, IW ;
CLARKE, BF .
ANNALS OF INTERNAL MEDICINE, 1980, 92 (02) :308-311
[5]  
FERRARIDILEO G, 1987, INVEST OPHTH VIS SCI, V28, P1747
[6]   MEASUREMENT OF VOLUME OF RESIDUAL URINE USING HIPPURAN-I-131 AND GAMMA CAMERA [J].
KALIS, E ;
LIKOURINAS, M ;
DERMENTZOGLOU, F ;
SAMARA, B ;
GOULANDRIS, N .
BRITISH JOURNAL OF UROLOGY, 1975, 47 (05) :567-570
[7]   RISK OF EARLY-ONSET PROLIFERATIVE RETINOPATHY IN IDDM IS CLOSELY RELATED TO CARDIOVASCULAR AUTONOMIC NEUROPATHY [J].
KROLEWSKI, AS ;
BARZILAY, J ;
WARRAM, JH ;
MARTIN, BC ;
PFEIFER, M ;
RAND, LI .
DIABETES, 1992, 41 (04) :430-437
[8]  
Mehta Sudhir, 2002, J Indian Med Assoc, V100, P141
[9]   Slow gastric emptying in type I diabetes: Relation to autonomic and peripheral neuropathy, blood glucose, and glycemic control [J].
Merio, R ;
Festa, A ;
Bergmann, H ;
Eder, T ;
Eibl, N ;
StacherJanotta, G ;
Weber, U ;
Budka, C ;
Heckenberg, A ;
Bauer, P ;
Francesconi, M ;
Schernthaner, G ;
Stacher, G .
DIABETES CARE, 1997, 20 (03) :419-423
[10]  
PELAYO JC, 1989, TXB NEPHROLOGY, P65