Antineoplastic agents.: 520.: Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa

被引：127

作者：

Pettit, GR ^{[1
]}

Xu, JP

Chapuis, JC

Pettit, RK

Tackett, LP

Doubek, DL

Hooper, JNA

Schmidt, JM

机构：

[1] Arizona State Univ, Inst Canc Res, Tempe, AZ 85287 USA

[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

[3] Queensland Museum, Sessible Marine Invertebrates, Brisbane, Qld 4101, Australia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 05期

关键词：

D O I：

10.1021/jm030207d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI(50) from 0.001 to <0.0001 mug/mL) murine and human cancer cell growth inhibitors. Both were isolated (10(-3)-10(-4)% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC, and ROESY) spectroscopy, revealed the unusual structures 1 and 2.

引用

页码：1149 / 1152

页数：4

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