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Free radicals associated with DNA damage

被引：91
作者：
Chatgilialoglu, C
O'Neill, P
机构：
[1] CNR, ICOCEA, I-40129 Bologna, Italy
[2] MRC, Radiat & Genome Stabil Unit, Didcot OX11 0RD, Oxon, England
来源：
EXPERIMENTAL GERONTOLOGY | 2001年 / 36卷 / 09期
关键词：
DNA; free radicals; damage;
D O I：
10.1016/S0531-5565(01)00132-2
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
This short review focuses on the chemical events related to DNA damage induced by free radicals. Diffusible hydroxyl radicals (HO) are able to react with either the sugar units by hydrogen abstraction or with the base moieties by addition. Selectively generated carbon-centred radicals at C1', C4' and C5' in model nucleosides or oligonucleotides and their subsequent fate under aerobic or anoxic condition are discussed by rationalisation of the available kinetic data. Reaction paths for the formation of nucleobase modifications such as 8-oxoG and FapyG, amplification of base damage, and tandem lesions are also discussed. Some types of DNA damage may be poorly repaired leading to deleterious genetic changes with time. (C) 2001 Elsevier Science Inc. All rights reserved.
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收藏
页码：1459 / 1471
页数：13
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