Human PACAP response gene 1 (p22/PRG1):: Proliferation-associated expression in pancreatic carcinoma cells

被引：32

作者：

Schäfer, H ^{[1
]}

Lettau, P ^{[1
]}

Trauzold, A ^{[1
]}

Banasch, M ^{[1
]}

Schmidt, WE ^{[1
]}

机构：

[1] Univ Kiel, Dept Med 1, Lab Mol Gastroenterol & Hepatol, D-24105 Kiel, Germany

来源：

PANCREAS | 1999年 / 18卷 / 04期

关键词：

early response gene; growth factor; stress response; cellular adaptation;

D O I：

10.1097/00006676-199905000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

p22/PACAP response gene-1 (PRG1) is a novel rat early response gene expressed during induction of proliferation and stress response. In humans, a homolog of p22/PRG1, designated IEX-1/DIF-2, exists, yet the exact function of this gene remains elusive. To characterize the expression of p22/PRG1 in human cancers, we analyzed the expression of p22/PRG1 in the human pancreatic carcinoma cell lines 818-4, PT45, and Panc-Tul. Serum or,growth factors, like epidermal growth factor (EGF) and hepatocyte growth factor (HGF), rapidly and transiently induced transcription of p22/PRG1 in these cells, correlating with the mitogenic response. Treatment with TNF-alpha was followed by a rapid increase of p22/PRG1 messenger RNA (mRNA) levels in PT45 and Panc-Tul cells, which proliferate in the presence of TNF-alpha, but not in 818-4 cells, which are growth-inhibited when treated with TNF-alpha. Our findings suggest that human p22/PRG1 is expressed in various pancreatic carcinoma cells as a growth-associated early response gene.

引用

页码：378 / 384

页数：7

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