Total synthesis of reblastatin

被引:59
作者
Wrona, IE
Gabarda, AE
Evano, G
Panek, JS
机构
[1] Boston Univ, Metcalf Ctr Sci & Engn, Dept Chem, Boston, MA 02215 USA
[2] Boston Univ, Metcalf Ctr Sci & Engn, Ctr Chem Methodol & Lib Dev, Boston, MA 02215 USA
关键词
D O I
10.1021/ja055384d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramolecular Buchwald-like amidation reaction to close the 19-membered macrolactam. Copyright © 2005 American Chemical Society.
引用
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页码:15026 / 15027
页数:2
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