A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

被引：205

作者：

Reich, D ^{[1
]}

Patterson, N

De Jager, PL

McDonald, GJ

Waliszewska, A

Tandon, A

Lincoln, RR

DeLoa, C

Fruhan, SA

Cabre, P

Bera, O

Semana, G

Kelly, MA

Francis, DA

Ardlie, K

Khan, O

Cree, BAC

Hauser, SL

Oksenberg, JR

Hafler, DA

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02138 USA

[3] MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02139 USA

[4] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[7] Hop Quitman, Neurol Clin, Fort De France, France

[8] Univ Rennes 1, Lab Univ Immunol, Rennes, France

[9] Estab Francais Sang Bretagne, Rennes, France

[10] Univ Hosp Birmingham, Dept Med, Div Med Sci, Birmingham, W Midlands, England

[11] Genom Collaborat, Cambridge, MA USA

[12] Wayne State Univ, Sch Med, Dept Neurol, Multiple Sclerosis Ctr, Detroit, MI 48201 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ng1646

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.

引用

页码：1113 / 1118

页数：6

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