Oral insulin delivery

被引:289
作者
Carino, GP [1 ]
Mathiowitz, E [1 ]
机构
[1] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02912 USA
关键词
diabetes; enteric coatings; microspheres; permeation enhancers; pH-sensitive polymers; protease inhibitors;
D O I
10.1016/S0169-409X(98)00075-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
An oral form of insulin has been the elusive goal for many investigators since the protein's initial discovery by Banting and Best in 1922. This paper will attempt to answer why this is the case by describing the substantial barriers to the development of oral insulin formulations. Following this description, specific strategies to overcome the barriers to oral insulin administration will be discussed. Most notably, the use of permeation enhancers, protease inhibitors, enteric coatings and polymer microsphere formulations will be covered, including commentary on which methods hold more promise towards the successful development of oral insulin. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
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页码:249 / 257
页数:9
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