[2.2]PHANEPHOS-ruthenium(II) complexes:: Highly active asymmetric catalysts for the hydrogenation of β-ketoesters

被引：100

作者：

Pye, PJ ^{[1
]}

Rossen, K ^{[1
]}

Reamer, RA ^{[1
]}

Volante, RP ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(98)00842-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The application of the planar chiral [2.2]PHANEPHOS ligand in the Ru(II)-catalyzed asymmetric hydrogenation of beta-ketoesters gave up to 96% ee involving a practical and reproducible procedure using the defined and readily prepared [2.2]PHANEPHOS-Ru(II)bis(trifluoroacetate) salt in the presence of a halide source. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：4441 / 4444

页数：4

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