Certainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiology

被引：102

作者：

Darwich, Laila ^{[1
,2
]}

Diaz, Ivan ^{[2
]}

Mateu, Enric ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Fac Vet, Dept Sanit & Anat Anim, Bellaterra 08193, Spain

[2] UAB IRTA, CReSA, Bellaterra 08193, Barcelona, Spain

来源：

VIRUS RESEARCH | 2010年 / 154卷 / 1-2期

关键词：

Porcine reproductive and respiratory; syndrome virus; Immunology; SYNDROME PRRS VIRUS; NF-KAPPA-B; ANTIBODY-DEPENDENT ENHANCEMENT; CELL-MEDIATED-IMMUNITY; GP5 NEUTRALIZATION EPITOPE; SCAVENGER RECEPTOR CD163; BLOOD MONONUCLEAR-CELLS; TOLL-LIKE RECEPTOR-3; ALVEOLAR MACROPHAGES; DENDRITIC CELLS;

D O I：

10.1016/j.virusres.2010.07.017

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most costly pathogens for the swine industry. Since its emergence some 20 years ago, much has been learned about the immunobiology of PRRSV. Although vaccines are available, they do not provide full and universal protection against PRRSV infection. In the present review, current knowledge on the virus's immunobiology will be discussed including: role of viral receptors, innate immune response to the virus, regulation of the immune response by PRRSV, and the characteristics and role of adaptive immunity. In addition, some hypotheses for future research in this area are presented. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：123 / 132

页数：10

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