MOBI: a web server to define and visualize structural mobility in NMR protein ensembles

被引：31

作者：

Martin, Alberto J. M. ^{[1
]}

Walsh, Ian ^{[1
]}

Tosatto, Silvio C. E. ^{[1
]}

机构：

[1] Univ Padua, Dept Biol, I-35131 Padua, Italy

来源：

BIOINFORMATICS | 2010年 / 26卷 / 22期

关键词：

DOMAINS;

D O I：

10.1093/bioinformatics/btq537

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: MOBI is a web server for the identification of structurally mobile regions in NMR protein ensembles. It provides a binary mobility definition that is analogous to the commonly used definition of intrinsic disorder in X-ray crystallographic structures. At least three different use cases can be envisaged: ( i) visualization of NMR mobility for structural analysis; ( ii) definition of regions for reliable comparative modelling in protein structure prediction and (iii) definition of mobility in analogy to intrinsic disorder. MOBI uses structural superposition and local conformational differences to derive a robust binary mobility definition that is in excellent agreement with the manually curated definition used in the CASP8 experiment for intrinsic disorder in NMR structure. The output includes mobility-coloured PDB files, mobility plots and a FASTA formatted sequence file summarizing the mobility results.

引用

页码：2916 / 2917

页数：2

共 15 条

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