Dietary lignin, an insoluble fiber, enhanced uterine cancer but did not influence mammary cancer induced by N-methyl-N-nitrosourea in rats

被引:6
作者
Birt, DF [1 ]
Markin, RS
Blackwood, D
Harvell, DME
Shull, JD
Pennington, KL
机构
[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA
[2] Univ Nebraska, Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA
[3] Univ Nebraska, Med Ctr, Dept Pathol Microbiol, Omaha, NE 68198 USA
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1998年 / 31卷 / 01期
关键词
D O I
10.1080/01635589809514674
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Previous investigations suggested potential breast cancer-preventive properties of dietary fiber from cabbage. The purpose of the present investigation was to determine whether lignin, a component of cabbage fiber, would protect against mammary carcinogenesis by N-methyl-N-nitroso-urea (MNU) in Sprague-Dawley rats. A six-week study was conducted using diets containing 0.5-5% dietary wood lignin (a readily.available, purified source). These diets were well tolerated by the rats, and a carcinogenesis study using 5 mg MNU/100 g body wt iv at 50 days of age was conducted, with the 2.5% lignin diet fed from 6 through 8 weeks of age followed by 5% lignin diet until 20 weeks after MNU. Dietary lignin and MNU treatment increased food consumption (p < 005), and body weight was slightly reduced at 10 and 20 weeks after MNU in the MNU-5% lignin diet group (p < 0.05). Serum estradiol was not altered by dietary lignin or MNU treatment, but uterine weights were highest in the MNU-control diet group 4 and 12 weeks after MNU. Expression of creatine kinase B, an estrogen-responsive gene, was lower in the uteri of the MNU-lignin diet group than in other groups at 20 weeks. Mammary carcinogenesis was not altered by dietary lignin. However, uterine endometrial adenocarcinoma was observed only in the MNU-lignin diet group (4 carcinomas/40 effective rats) (p < 005).
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页码:24 / 30
页数:7
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