Atypical BCR-ABL mRNA transcripts in adult Acute lymphoblastic leukemia

被引：40

作者：

Burmeister, Thomas ^{[1
]}

Schwartz, Stefan ^{[1
]}

Taubald, Almut ^{[2
]}

Jost, Edgar ^{[3
]}

Lipp, Thomas ^{[4
]}

Schneller, Folker ^{[5
]}

Diedrich, Helmut ^{[6
]}

Thomssen, Henrike ^{[7
]}

Mey, Ulrich J. M. ^{[8
]}

Eucker, Jan ^{[9
]}

Rieder, Harald ^{[10
]}

Goekbuget, Nicola ^{[11
]}

Hoelzer, Dieter ^{[11
]}

Thiel, Eckhard ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Campus Benjamin Franklin, Med Klin 3, Hindenburgdamm 30, D-12200 Berlin, Germany

[2] Friedrich Alexander Univ, Med Klin 3, Erlangen, Germany

[3] Rhein Westfalische TH, Med Klin 4, Aachen, Germany

[4] Stadt Klinikum Munchen GmbH, Klinikum Schwabing, Med Abt 1, Munich, Germany

[5] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, Munich, Germany

[6] Med Hsch, Hamatol Hamostaseol & Onkol, Hannover, Germany

[7] Klinikum Bremen Mitte, Med Klin 1, Bremen, Germany

[8] Rheinische Friedrich Wilhelms Univ, Med Klin & Poliklin 1, Bonn, Germany

[9] Charite Univ Med Berlin, Med Klin 2, Berlin, Germany

[10] Heinrich Heine Univ, Inst Humangenet & Anthropol, Dusseldorf, Germany

[11] Goethe Univ Frankfurt, Med Klin 2, Frankfurt, Germany

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 12期

关键词：

acute lymphoblastic leukemia; BCR-ABL; PCR;

D O I：

10.3324/haematol.11737

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

RT-PCR detects chimeric BCR-ABL mRNA in approximately 25% of adult acute lymphoblastic leukemia (ALL) cases. Minor breakpoint transcripts (e1a2) are found in about 70% of positive cases and major breakpoint transcripts (e13a2, e14a2) in about 30% of cases. However, other atypical transcripts are sometimes observed. We report experience gained in the GMALL Study Group and identified 8 BCR-ABL-positive adult ALL cases with such atypical transcripts: 5 with e1a3, 2 with e13a3 (b2a3), and 1 with e6a2. This corresponds to a prevalence of 1-2% of all BCR-ABL-positive cases. The clinical courses are reported and diagnostic proposals are made.

引用

页码：1699 / 1702

页数：4

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