Muraymycins, novel peptidoglycan biosynthesis inhibitors: Synthesis and SAR of their analogues

被引：62

作者：

Yamashita, A ^{[1
]}

Norton, E ^{[1
]}

Petersen, PJ ^{[1
]}

Rasmussen, BA ^{[1
]}

Singh, G ^{[1
]}

Yang, YJ ^{[1
]}

Mansour, TS ^{[1
]}

Ho, DM ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Chem Sci & Infect Dis, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00671-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A Series Of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against grain-positive organisins. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3345 / 3350

页数：6

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