Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells

被引:48
作者
delaTorre, JC [1 ]
Mallory, M [1 ]
Brot, M [1 ]
Gold, L [1 ]
Koob, G [1 ]
Oldstone, MBA [1 ]
Masliah, E [1 ]
机构
[1] UNIV CALIF SAN DIEGO, DEPT NEUROSCI, LA JOLLA, CA 92093 USA
关键词
D O I
10.1006/viro.1996.0340
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Neurons have a restricted expression of MHC heavy chain molecules which prevents presentation of antigens of infecting viruses. As a result, such infected cells escape immune surveillance and allow the establishment of noncytolytic persistent infection. Here we show that a chronic noncytolytic viral infection both in vitro and in vivo selectively perturbed the expression of GAP-43, a protein that plays a central role in neuronal plasticity processes accompanying learning and memory. GAP-43 expression was greatly decreased in the hippocampus, an area of heightened viral replication, while synaptic density was preserved. Concurrently, the ability to learn tasks was significantly impaired in these persistently infected mice. Yet, infected neurons remained free from structural injury. (C) 1996 Academic Press, Inc.
引用
收藏
页码:508 / 515
页数:8
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