Cloning and chromosomal mapping of bovine interleukin-2 receptor gamma gene

被引：6

作者：

Yoo, J

Stone, RT

SolinasToldo, S

Fries, R

Beattie, CW

机构：

[1] USDA ARS,MEAT ANIM RES CTR,CLAY CTR,NE 68933

[2] GERMAN CANC RES CTR,ORG COMPLEX GENOMES,D-69120 HEIDELBERG,GERMANY

[3] TECH UNIV MUNICH,LEHRSTUHL TIERZUCHT,D-85350 FREISING,GERMANY

来源：

DNA AND CELL BIOLOGY | 1996年 / 15卷 / 06期

关键词：

D O I：

10.1089/dna.1996.15.453

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-2 receptor (IL-2R) gamma chain, a member of the cytokine receptor superfamily, forms a high-affinity receptor with IL-2R alpha and beta chains that plays an important role in interleukin-2 (IL-2) signal transduction, We have cloned and characterized the bovine IL-2R gamma gene and corresponding cDNA. Bovine IL-2R gamma is a single-copy gene that contains 8 exons and spans approximately 3.8 kb, The promoter region lacks conventional TATA and CCAAT consensus sites, but contains several regulatory elements that are recognition sites for the GATA binding proteins, AP-1 and AP-2, Physical assignment by fluorescence in situ hybridization (FISH) placed the bovine IL-2R gamma gene on chromosome Xq23.

引用

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页码：453 / 459

页数：7

相关论文

共 34 条

[1] RECONSTITUTION OF FUNCTIONAL INTERLEUKIN-2 RECEPTOR COMPLEXES ON FIBROBLASTOID CELLS - INVOLVEMENT OF THE CYTOPLASMIC DOMAIN OF THE GAMMA-CHAIN IN 2 DISTINCT SIGNALING PATHWAYS [J].

ASAO, H ;

TAKESHITA, T ;

ISHII, N ;

KUMAKI, S ;

NAKAMURA, M ;

SUGAMURA, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :4127-4131

[2]

BOSCO MC, 1994, BLOOD, V83, P3462

[3] CHARACTERIZATION OF CDNAS ENCODING THE MURINE INTERLEUKIN-2 RECEPTOR (IL-2R) GAMMA-CHAIN - CHROMOSOMAL MAPPING AND TISSUE-SPECIFICITY OF IL-2R GAMMA-CHAIN EXPRESSION [J].

CAO, XQ ;

KOZAK, CA ;

LIU, YJ ;

NOGUCHI, M ;

OCONNELL, E ;

LEONARD, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) :8464-8468

[4]

DESAINTBASILE G, 1987, P NATL ACAD SCI USA, V84, P7576

[5] INTERNATIONAL SYSTEM FOR CYTOGENETIC NOMENCLATURE OF DOMESTIC-ANIMALS (1989) - THE 2ND INTERNATIONAL-CONFERENCE ON STANDARDIZATION OF DOMESTIC-ANIMAL KARYOTYPES [J].

DIBERARDINO, D ;

HAYES, H ;

FRIES, R ;

LONG, S .

CYTOGENETICS AND CELL GENETICS, 1990, 53 (2-3) :65-79

[6] EXPRESSION OF INTERLEUKIN-2 RECEPTOR-GAMMA ON HUMAN MONOCYTES - CHARACTERIZATION OF LINEAGE-SPECIFIC POSTTRANSLATIONAL MODIFICATIONS [J].

EPLINGBURNETTE, PK ;

WEI, S ;

LIU, JH ;

PERICLE, F ;

USSERY, DW ;

RUSSELL, SM ;

LEONARD, WJ ;

DJEU, JY .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (01) :291-294

[7] COMPILATION OF VERTEBRATE-ENCODED TRANSCRIPTION FACTORS [J].

FAISST, S ;

MEYER, S .

NUCLEIC ACIDS RESEARCH, 1992, 20 (01) :3-26

[8] UTILIZATION OF THE BETA-CHAIN AND GAMMA-CHAIN OF THE IL-2 RECEPTOR BY THE NOVEL CYTOKINE-IL-15 [J].

GIRI, JG ;

AHDIEH, M ;

EISENMAN, J ;

SHANEBECK, K ;

GRABSTEIN, K ;

KUMAKI, S ;

NAMEN, A ;

PARK, LS ;

COSMAN, D ;

ANDERSON, D .

EMBO JOURNAL, 1994, 13 (12) :2822-2830

[9] PHOSPHORYLATION AND ACTIVATION OF THE JAK-3 JANUS KINASE IN RESPONSE TO INTERLEUKIN-2 [J].

JOHNSTON, JA ;

KAWAMURA, M ;

KIRKEN, RA ;

CHEN, YQ ;

BLAKE, TB ;

SHIBUYA, K ;

ORTALDO, JR ;

MCVICAR, DW ;

O'SHEA, JJ .

NATURE, 1994, 370 (6485) :151-153

[10] SH2 AND SH3 DOMAINS - ELEMENTS THAT CONTROL INTERACTIONS OF CYTOPLASMIC SIGNALING PROTEINS [J].

KOCH, CA ;

ANDERSON, D ;

MORAN, MF ;

ELLIS, C ;

PAWSON, T .

SCIENCE, 1991, 252 (5006) :668-674

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