Label-free optical biosensing with slot-waveguides

被引：174

作者：

Barrios, Carlos A. ^{[1
]}

Banuls, Maria Jose ^{[2
]}

Gonzalez-Pedro, Victoria ^{[2
]}

Gylfason, Kristinn B. ^{[3
]}

Sanchez, Benito ^{[4
]}

Griol, Amadeu ^{[4
]}

Maquieira, A. ^{[2
]}

Sohlstrom, H. ^{[3
]}

Holgado, M. ^{[5
]}

Casquel, R. ^{[5
]}

机构：

[1] Univ Politecn Madrid, Inst Sistemas Optoelect & Microtecnol, ETSI Telecomunicac, E-28040 Madrid, Spain

[2] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

[3] Royal Inst Technol, Sch Elect Engn, Microsyst Technol Lab, SE-10044 Stockholm, Sweden

[4] Univ Politecn Valencia, Ctr Tecnol Nanofoton, Valencia 46022, Spain

[5] Univ Politecn Madrid, Ctr Laser, Madrid 28031, Spain

来源：

OPTICS LETTERS | 2008年 / 33卷 / 07期

关键词：

D O I：

10.1364/OL.33.000708

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate label-free molecule detection by using an integrated biosensor based on a Si3N4/SiO2 Slot-waveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm/(ng/mm(2)) for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg/mm(2) for anti-BSA and BSA, respectively, limited by wavelength resolution. (C) 2008 Optical Society of America.

引用

页码：708 / 710

页数：3

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