Applications of Molecular Imaging in Drug Discovery and Development Process

被引:25
作者
Ahn, Byeong-Cheol [1 ]
机构
[1] Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Taegu, South Korea
关键词
Drug discovery and development process; molecular imaging; drug screening; pharmacokinetic study; preclinical and clinical study; personalized medicine; lesionalized medicine; PROTEIN-PROTEIN INTERACTIONS; TUMOR RESPONSE; BREAST-CANCER; DIFFERENTIATION; SPECTROSCOPY; DIFFUSION; PERFUSION; SPECT/CT; PROBES; PET/CT;
D O I
10.2174/138920111795163904
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The process of drug discovery and development requires enormous resources and time, with increasing cost for new drug development. Molecular imaging techniques have tremendous potential for improving the efficiency of drug screening, assessing the pharmacokinetics of new drugs, and evaluating drug effects. Appropriate application of molecular imaging to drug discovery and development can markedly reduce costs and the time required for new drug development. This review focuses on the contributions of molecular imaging for drug discovery and development, particularly drug screening, pharmacokinetic, preclinical and clinical drug evaluation, and for personalized and lesionalized medicine.
引用
收藏
页码:459 / 468
页数:10
相关论文
共 61 条
[1]   Estimating the cost of new drug development: Is it really $802 million? [J].
Adams, CP ;
Brantner, VV .
HEALTH AFFAIRS, 2006, 25 (02) :420-428
[2]   Protein-protein interactions as a target for drugs in proteomics [J].
Archakov, AI ;
Govorun, VM ;
Dubanov, AV ;
Ivanov, YD ;
Veselovsky, AV ;
Lewi, P ;
Janssen, P .
PROTEOMICS, 2003, 3 (04) :380-391
[3]   Response to Therapy in Breast Cancer [J].
Avril, Norbert ;
Sassen, Stefanie ;
Roylance, Rebecca .
JOURNAL OF NUCLEAR MEDICINE, 2009, 50 :55S-63S
[4]   The future of cancer imaging [J].
Benaron, DA .
CANCER AND METASTASIS REVIEWS, 2002, 21 (01) :45-78
[5]   Diffusion Tensor Imaging in a Human PET/MR Hybrid System [J].
Boss, Andreas ;
Kolb, Armin ;
Hofmann, Matthias ;
Bisdas, Sotirios ;
Naegele, Thomas ;
Ernemann, Ulrike ;
Stegger, Lars ;
Rossi, Cristina ;
Schlemmer, Heinz-Peter ;
Pfannenberg, Christina ;
Reimold, Matthias ;
Claussen, Claus D. ;
Pichler, Bernd J. ;
Klose, Uwe .
INVESTIGATIVE RADIOLOGY, 2010, 45 (05) :270-274
[6]   Fluorescence-based methods in the study of protein-protein interactions in living cells [J].
Ciruela, Francisco .
CURRENT OPINION IN BIOTECHNOLOGY, 2008, 19 (04) :338-343
[7]   A new tool for molecular imaging:: The microvolumetric β blood counter [J].
Convert, Laurence ;
Morin-Brassard, Guillaume ;
Cadorette, Jules ;
Archambault, Melanie ;
Bentourkia, M'hamed ;
Lecomte, Roger .
JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (07) :1197-1206
[8]   Conformational behaviour determines the low-relaxivity state of a conditional MRI contrast agent [J].
Cosentino, Ugo ;
Pitea, Demetrio ;
Moro, Giorgio ;
Saracino, Gloria A. A. ;
Villa, Alessandra .
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2009, 11 (20) :3943-3950
[9]   Human in vitro reporter model of neuronal development and early differentiation processes [J].
Couillard-Despres, Sebastien ;
Quehl, Eike ;
Altendorfer, Katrin ;
Karl, Claudia ;
Ploetz, Sonja ;
Bogdahn, Ulrich ;
Winkler, Juergen ;
Aigner, Ludwig .
BMC NEUROSCIENCE, 2008, 9 (1)
[10]   Molecular imaging in the development of cancer therapeutics [J].
Czernin, J ;
Weber, WA ;
Herschman, HR .
ANNUAL REVIEW OF MEDICINE, 2006, 57 :99-118