The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development

被引：51

作者：

Söhl, G

Eiberger, J

Jung, YT

Kozak, CA

Willecke, K ^{[1
]}

机构：

[1] Univ Bonn, Inst Genet, Abt Mol Genet, D-53117 Bonn, Germany

[2] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

来源：

BIOLOGICAL CHEMISTRY | 2001年 / 382卷 / 06期

关键词：

connexin subgroup; Cx29; human Cx30.2; oligodendrocytes; peripheral nerves; spinal cord;

D O I：

10.1515/BC.2001.122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel mouse gap junction gene, coding for a presumptive protein of 258 amino acids (molecular mass: 28 981 Da), has been designated connexin29. This single copy gene was mapped to distal mouse chromosome 5 and shows 75% sequence identity to a human connexin30.2 sequence in the database. Connexin29 mRNA (4.4 kb) is highly expressed in mouse sciatic nerve and less abundant in spinal cord as well as in adult brain, where it increased 12-fold between day 7 and 14 post partum. Our expression data suggest that the new connexin gene is active in myelin-forming glial cells.

引用

页码：973 / 978

页数：6

共 40 条

[1] Studies in transgenic mice indicate a loss of connexin32 function in X-linked Charcot-Marie-tooth disease [J].