Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes

被引：124

作者：

Philipp, M ^{[1
]}

Hein, L ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany

来源：

PHARMACOLOGY & THERAPEUTICS | 2004年 / 101卷 / 01期

关键词：

adrenergic receptors; genetically altered mice; G protein-coupled receptors; receptor signaling;

D O I：

10.1016/j.pharmthera.2003.10.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The biological effects of epinephrine and norepinephrine are mediated via 9 different adrenergic receptor subtypes, which all belong to the superfamily of G protein-coupled receptors. Although pharmacological ligands for adrenergic receptors have an important place in medical therapy, the full therapeutic potential of the 9 adrenergic receptor subtypes has not been explored yet. To dissect the physiological relevance of adrenergic receptor subtype diversity, gene-targeted mouse models carrying deletions in these receptor genes ("knockout mice") have been generated. This review gives an overview of the phenotypes observed in mice deficient in adrenergic receptors and discusses the therapeutic relevance of subtype-specific drug therapy. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：65 / 74

页数：10

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