Simultaneous determination of tetrabromobisphenol A, tetrachlorobisphenol A, bisphenol A and other halogenated analogues in sediment and sludge by high performance liquid chromatography-electrospray tandem mass spectrometry

被引:148
作者
Chu, SG [1 ]
Haffner, GD [1 ]
Letcher, RJ [1 ]
机构
[1] Univ Windsor, Great Lakes Inst Environm Res, Windsor, ON N9B 3P4, Canada
基金
加拿大创新基金会;
关键词
liquid chromatography tandem mass spectrometry; BPA; TCBPA; TBBPA; sludge; sediment;
D O I
10.1016/j.chroma.2005.08.007
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A high performance liquid chromatography-electrospray (negative) ionization-tandem mass spectrometry (HPLC-ESI(-)-MS-MS) based method has been developed for simultaneous determination of bisphenol A (BPA), tetrachlorobisphenol A (TCBPA), and tetrabromobisphenol A (TBBPA), as well as lower brominated BPA analogues in sediment and sludge samples. samples were extracted with MTBE, target compounds were partitioned by aqueous solution of sodium hydroxide. The solution was subsequently acidified, and the enrichment and desalting were performed via solid phase extraction (SPE). After cleanup the target compounds were determined by HPLC-ES1(-)-MS-MS. The method limits of quantification (MLOQs) from sediment and sludge for BPA, monobromo-bisphenol A (mono-BBPA), dibromo-bisphenol A (di-BBPA), tribromo-bisphenol A (tri-BBPA), TBBPA and TCBPA were 0.15,0.02,0.02,0.04,0.05, and 0.03 ng/g (dry weight), respectively. Mean recovery of the analytes from spiked samples ranged from 70 to 105%, and the relative standard deviation ranged from 4.9 to 13.1%. The method was successfully applied to sediment and sludge samples analysis. (c) 2005 Elsevier B.V. All rights reserved.
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页码:25 / 32
页数:8
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