VWF meets the ADAMTS family

被引：6

作者：

Brass, L ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 11期

关键词：

D O I：

10.1038/nm1101-1177

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The etiology of thrombotic thrombocytopenic purpura (TTP), a severe blood disorder resulting from increased platelet activation, has been an enigma. The identification of ADAMTS as a protease that cleaves von Willebrand factor and the demonstration of ADAMTS mutations in families with inherited TTP suggest a molecular mechanism for the disease.

引用

页码：1177 / 1178

页数：2

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