Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

被引：74

作者：

De Graaf, Carolyn A. ^{[1
,5
]}

Choi, Jarny ^{[1
,5
]}

Baldwin, Tracey M. ^{[1
]}

Bolden, Jessica E. ^{[1
,5
]}

Fairfax, Kirsten A. ^{[1
,5
]}

Robinson, Aaron J. ^{[1
,5
]}

Biben, Christine ^{[1
,5
]}

Morgan, Clare ^{[1
,5
]}

Ramsay, Kerry ^{[1
]}

Ng, Ashley P. ^{[2
,5
]}

Kauppi, Maria ^{[2
,5
]}

Kruse, Elizabeth A. ^{[1
,5
]}

Sargeant, Tobias J. ^{[1
,5
]}

Seidenman, Nick ^{[1
]}

D'Amico, Angela ^{[3
]}

D'Ombrain, Marthe C. ^{[1
,7
]}

Lucas, Erin C. ^{[1
]}

Koernig, Sandra ^{[7
]}

Morelli, Adriana Baz ^{[7
]}

Wilson, Michael J. ^{[7
]}

Dower, Steven K. ^{[7
]}

Williams, Brenda ^{[8
,9
]}

Heazlewood, Shen Y. ^{[8
,9
]}

Hu, Yifang ^{[4
]}

Nilsson, Susan K. ^{[8
,9
]}

Wu, Li ^{[3
,10
]}

Smyth, Gordon K. ^{[4
,6
]}

Alexander, Warren S. ^{[2
,5
]}

Hilton, Douglas J. ^{[1
,5
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Mol Med Div, Parkville, Vic 3052, Australia

[2] Walter & Eliza Hall Inst Med Res, Canc & Haematol Div, Parkville, Vic 3052, Australia

[3] Walter & Eliza Hall Inst Med Res, Mol Immunol Div, Parkville, Vic 3052, Australia

[4] Walter & Eliza Hall Inst Med Res, Bioinformat Div, Parkville, Vic 3010, Australia

[5] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

[6] Univ Melbourne, Dept Math & Stat, Parkville, Vic 3052, Australia

[7] CSL Ltd, Parkville, Vic 3052, Australia

[8] CSIRO Mfg, Biomed Mfg, Clayton, Vic 3169, Australia

[9] Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, Australia

[10] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China

来源：

STEM CELL REPORTS | 2016年 / 7卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

GENE; DIFFERENTIATION; NETWORKS;

D O I：

10.1016/j.stemcr.2016.07.007

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.

引用

页码：571 / 582

页数：12

共 16 条

[1] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].