Synaptic plasticity in cortical systems

被引：166

作者：

Klintsova, AY

Greenough, WT

机构：

[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0959-4388(99)80028-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies indicate that synapse addition and/or loss is associated with different types of learning. Other factors influencing synaptogenesis and synapse loss include neurotrophins, hormones, and the induction of long-term potentiation. An emerging view of synaptic plasticity suggests that local neurotrophin action and synaptically associated protein synthesis may promote synaptic remodelling and changes in receptor expression or activation.

引用

收藏

页码：203 / 208

页数：6

相关论文

共 79 条

[1]

Akaneya Y, 1997, J NEUROSCI, V17, P6707

[2] Long-term potentiation and spatial training are both associated with the generation of new excitatory synapses [J].

Andersen, P ;

Soleng, AF .

BRAIN RESEARCH REVIEWS, 1998, 26 (2-3) :353-359

[3] Motor-skill learning: Changes in synaptic organization of the rat cerebellar cortex [J].

Anderson, BJ ;

Alcantara, AA ;

Greenough, WT .

NEUROBIOLOGY OF LEARNING AND MEMORY, 1996, 66 (02) :221-229

[4] Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes:: A possible factor regulating synaptic protein synthesis [J].

Angenstein, F ;

Greenough, WT ;

Weiler, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :15078-15083

[5] Fast actions of neurotrophic factors [J].

Berninger, B ;

Poo, MM .

CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (03) :324-330

[6] LEARNING CAUSES SYNAPTOGENESIS, WHEREAS MOTOR-ACTIVITY CAUSES ANGIOGENESIS, IN CEREBELLAR CORTEX OF ADULT-RATS [J].

BLACK, JE ;

ISAACS, KR ;

ANDERSON, BJ ;

ALCANTARA, AA ;

GREENOUGH, WT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5568-5572

[7]

BLACK JE, 1998, HDB CHILD ADOLESCENT, V6, P31

[8] Neurotrophins and activity-dependent development of the neocortex [J].

Bonhoeffer, T .

CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (01) :119-126

[9] Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses [J].

Buchs, PA ;

Muller, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :8040-8045

[10] Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns [J].

Cabelli, RJ ;

Shelton, DL ;

Segal, RA ;

Shatz, CJ .

NEURON, 1997, 19 (01) :63-76

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