Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion

被引：12

作者：

Ma, RC ^{[1
]}

Szurszewski, JH ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN, DEPT PHYSIOL & BIOPHYS, ROCHESTER, MN 55905 USA

来源：

PEPTIDES | 1996年 / 17卷 / 01期

关键词：

calcitonin gene-related peptide; enkephalin; dynorphin; neurotensin; capsaicin; inferior mesenteric ganglion; dorsal root ganglion; guinea pig; prevertebral ganglia;

D O I：

10.1016/0196-9781(95)02064-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurons of the guinea pig IMG are surrounded by nerve fibers containing CGRP-like immunoreactivity (LI). The purpose of this study was to determine whether colonic distension releases CGRP-LI in the IMG and whether opioid peptides and neurotensin(8-13) [NT(8-13)] modulate its release. Colonic distension released CGRP-LI. Methionine-enkephalin acted through mu and/or delta receptors to block release. NT(8-13) had no effect on release of CGRP-LI. Capsaicin pretreatment reduced the content of CGRP-LI in the IMG by 37%. Colonic distension did not release CGRP-LI from capsaicin-insensitive fibers. The data suggest that colonic distension releases CGRP-LI material from capsaicin-sensitive nerves and that enkephalins modulate release of CGRP-LI.

引用

页码：161 / 170

页数：10

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