Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity

被引：20

作者：

Bogerd, Hal P. ^{[1
,2
]}

Zhang, Fengwen ^{[3
,4
]}

Bieniasz, Paul D. ^{[3
,4
]}

Cullen, Bryan R. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Ctr Virol, Durham, NC 27710 USA

[3] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10016 USA

[4] Rockefeller Univ, Lab Retrovirol, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

来源：

VIROLOGY | 2011年 / 410卷 / 01期

关键词：

XMRV; APOBEC3G; Innate immunity; Murine leukemia virus; Retrovirus; PROSTATE CARCINOMA-CELLS; CHRONIC-FATIGUE-SYNDROME; HUMAN RETROVIRUS XMRV; HIV-1; INFECTION; RESTRICTION; RESISTANCE; VIF; TISSUES; GENE;

D O I：

10.1016/j.virol.2010.11.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Xenotropic murine leukemia virus-related virus (XMRV) is a novel retrovirus, related to murine leukemia virus (MLV), that has been implicated in human disease. If XMRV is indeed able to replicate in humans, then one might predict that XMRV would have developed resistance to human innate antiviral resistance factors such as APOBEC3G (hA3G). In fact, we observed that XMRV and MLV are both highly sensitive to inhibition by hA3G and equally resistant to inhibition by murine APOBEC3. While several human prostate cancer cell lines were found to lack hA3G, stable expression of physiological levels of hA3G rendered these cells refractory to XMRV replication. Few human tissues fail to express hA3G, and we therefore hypothesize that XMRV replicates in one or more hA3G-negative reservoir tissues and/or that human XMRV infections are likely to be rare and potentially of zoonotic origin. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：234 / 239

页数：6

共 32 条

[1] Murine retrovirus escapes from murine APOBEC3 via two distinct novel mechanisms [J].

Abudu, Aierken ;

Takaori-Kondo, Akifumi ;

Izumi, Taisuke ;

Shirakawa, Kotaro ;

Kobayashi, Masayuki ;

Sasada, Amane ;

Fukunaga, Keiko ;

Uchiyama, Takashi .

CURRENT BIOLOGY, 2006, 16 (15) :1565-1570

[2] Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics [J].

Albin, John S. ;

Harris, Reuben S. .

EXPERT REVIEWS IN MOLECULAR MEDICINE, 2010, 12

[3] Cytidine deamination of retroviral DNA by diverse APOBEC proteins [J].

Bishop, KN ;

Holmes, RK ;

Sheehy, AM ;

Davidson, NO ;

Cho, SJ ;

Malim, MH .

CURRENT BIOLOGY, 2004, 14 (15) :1392-1396

[4] Cellular inhibitors of long interspersed element 1 and Alu retrotransposition [J].

Bogerd, Hal P. ;

Wiegand, Heather L. ;

Hulme, Amy E. ;

Garcia-Perez, Jose L. ;

O'Shea, K. Sue ;

Moran, John V. ;

Cullen, Bryan R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (23) :8780-8785

[5] MACROPHAGE-TROPIC HUMAN-IMMUNODEFICIENCY-VIRUS ISOLATES FROM DIFFERENT PATIENTS EXHIBIT UNUSUAL V3 ENVELOPE SEQUENCE HOMOGENEITY IN COMPARISON WITH T-CELL-TROPIC ISOLATES - DEFINITION OF CRITICAL AMINO-ACIDS INVOLVED IN CELL TROPISM [J].

CHESEBRO, B ;

WEHRLY, K ;

NISHIO, J ;

PERRYMAN, S .

JOURNAL OF VIROLOGY, 1992, 66 (11) :6547-6554

[6] Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors [J].

Cullen, BR .

JOURNAL OF VIROLOGY, 2006, 80 (03) :1067-1076

[7] Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid [J].

Derse, David ;

Hill, Shawn A. ;

Princler, Gerald ;

Lloyd, Patricia ;

Heidecker, Gisela .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (08) :2915-2920

[8] Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif [J].

Doehle, BP ;

Schäfer, A ;

Cullen, BR .

VIROLOGY, 2005, 339 (02) :281-288

[9] Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion [J].

Doehle, BP ;

Schäfer, A ;

Wiegand, HL ;

Bogerd, HP ;

Cullen, BR .

JOURNAL OF VIROLOGY, 2005, 79 (13) :8201-8207

[10] A third-generation lentivirus vector with a conditional packaging system [J].

Dull, T ;

Zufferey, R ;

Kelly, M ;

Mandel, RJ ;

Nguyen, M ;

Trono, D ;

Naldini, L .

JOURNAL OF VIROLOGY, 1998, 72 (11) :8463-8471

← 1 2 3 4 →