Development of a Mouse-Adapted Live Attenuated Influenza Virus That Permits In Vivo Analysis of Enhancements to the Safety of Live Attenuated Influenza Virus Vaccine

被引：35

作者：

Cox, Andrew ^{[1
]}

Baker, Steven F. ^{[1
]}

Nogales, Aitor ^{[1
]}

Martinez-Sobrido, Luis ^{[1
]}

Dewhurst, Stephen ^{[1
]}

机构：

[1] Univ Rochester, Dept Microbiol & Immunol, Rochester, NY 14627 USA

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 06期

关键词：

SEASONAL INFLUENZA; A/ANN ARBOR/6/60; YOUNG-CHILDREN; A VIRUS; EFFICACY; MICE; HEMAGGLUTININ; FERRETS; GENE; H2N2;

D O I：

10.1128/JVI.02636-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The live attenuated influenza virus vaccine (LAIV) is preferentially recommended for use in persons 2 through 49 years of age but has not been approved for children under 2 or asthmatics due to safety concerns. Therefore, increasing safety is desirable. Here we describe a murine LAIV with reduced pathogenicity that retains lethality at high doses and further demonstrate that we can enhance safety in vivo through mutations within NS1. This model may permit preliminary safety analysis of improved LAIVs.

引用

页码：3421 / 3426

页数：6

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