Isoterchebulin and 4,6-O-isoterchebuloyl-D-glucose, novel hydrolyzable tannins from Terminalia macroptera

被引:37
作者
Conrad, J
Vogler, B
Reeb, S
Klaiber, I
Papajewski, S
Roos, G
Vasquez, E
Setzer, MC
Kraus, W
机构
[1] Univ Hohenheim, Inst Chem, D-70599 Stuttgart, Germany
[2] Univ Alabama, Dept Chem, Huntsville, AL 35899 USA
[3] Univ Alabama, Dept Biol Sci, Huntsville, AL 35899 USA
[4] Visayas State Coll Agr, Dept Plant Protect, Baybay, Leyte, Philippines
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 03期
关键词
D O I
10.1021/np000506v
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new hydrolyzable tannins, isoterchebulin (1) and 4,6-O-isoterchebuloyl-D-glucose (2), together with six known tannins, 3-8, were isolated from the bark of Terminalia macroptera. Their structures were elucidated by extensive 1D and 2D NMR studies, MS, and chemical transformations. Biological activities of all compounds were evaluated against the snail Biomphalaria glabrata, the bacteria Bacillus subtilis and Pseudomonas fluorescens, the nematode Caenorhabditis elegans, and four cancer cell lines (Hep G2, MCF-7/S, MDA-M8-231, and 5637 cells). All compounds except 3 showed antimicrobial activities against B. subtilis (MIC 8-64 mug/mL), whereas only 1 was active against C. elegans (100 mug/mL) and B. glabrata (LC100 = 60 mug/mL). 3 and 8 were toxic against 5637 cells with LC50 = 84.66 and 41.40 CIM, respectively.
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收藏
页码:294 / 299
页数:6
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