共 126 条
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins
被引:306
作者:

Serganov, Alexander
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机构:
Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

Patel, Dinshaw J.
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Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA
机构:
[1] Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA
关键词:
D O I:
10.1038/nrg2172
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Although various functions of RNA are carried out in conjunction with proteins, some catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little or no assistance from proteins. Furthermore, the discovery of metabolite-sensing riboswitches and other types of RNA sensors has revealed RNA-based mechanisms that cells use to regulate gene expression in response to internal and external changes. Structural studies have shown how these RNAs can carry out a range of functions. In addition, the contribution of ribozymes and riboswitches to gene expression is being revealed as far more widespread than was previously appreciated. These findings have implications for understanding how cellular functions might have evolved from RNA-based origins.
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页码:776 / 790
页数:15
相关论文
共 126 条
[61]
DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcription
[J].
Majdalani, N
;
Cunning, C
;
Sledjeski, D
;
Elliott, T
;
Gottesman, S
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (21)
:12462-12467

Majdalani, N
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

Cunning, C
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

Sledjeski, D
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

Elliott, T
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

Gottesman, S
论文数: 0 引用数: 0
h-index: 0
机构: NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[62]
Adenine riboswitches and gene activation by disruption of a transcription terminator
[J].
Mandal, M
;
Breaker, RR
.
NATURE STRUCTURAL & MOLECULAR BIOLOGY,
2004, 11 (01)
:29-35

Mandal, M
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Breaker, RR
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[63]
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
[J].
Mandal, M
;
Boese, B
;
Barrick, JE
;
Winkler, WC
;
Breaker, RR
.
CELL,
2003, 113 (05)
:577-586

Mandal, M
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Boese, B
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Barrick, JE
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Winkler, WC
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Breaker, RR
论文数: 0 引用数: 0
h-index: 0
机构:
Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[64]
A glycine-dependent riboswitch that uses cooperative binding to control gene expression
[J].
Mandal, M
;
Lee, M
;
Barrick, JE
;
Weinberg, Z
;
Emilsson, GM
;
Ruzzo, WL
;
Breaker, RR
.
SCIENCE,
2004, 306 (5694)
:275-279

Mandal, M
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Lee, M
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Barrick, JE
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

论文数: 引用数:
h-index:
机构:

Emilsson, GM
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Ruzzo, WL
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

Breaker, RR
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[65]
Tertiary contacts distant from the active site prime a ribozyme for catalysis
[J].
Martick, Monika
;
Scott, William G.
.
CELL,
2006, 126 (02)
:309-320

Martick, Monika
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Santa Cruz, Ctr Mol Biol RNA, Santa Cruz, CA 95064 USA

Scott, William G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Cruz, Ctr Mol Biol RNA, Santa Cruz, CA 95064 USA Univ Calif Santa Cruz, Ctr Mol Biol RNA, Santa Cruz, CA 95064 USA
[66]
Coupled degradation of a small regulatory RNA and its mRNA targets in Escherichia coli
[J].
Massé, E
;
Escorcia, FE
;
Gottesman, S
.
GENES & DEVELOPMENT,
2003, 17 (19)
:2374-2383

Massé, E
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

Escorcia, FE
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

Gottesman, S
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[67]
Transcription termination control of the S box system:: Direct measurement of S-adenosylmethionine by the leader RNA
[J].
McDaniel, BAM
;
Grundy, FJ
;
Artsimovitch, I
;
Henkin, TM
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2003, 100 (06)
:3083-3088

McDaniel, BAM
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA

Grundy, FJ
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA

论文数: 引用数:
h-index:
机构:

Henkin, TM
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA
[68]
COMPARATIVE AND FUNCTIONAL-ANATOMY OF GROUP-II CATALYTIC INTRONS - A REVIEW
[J].
MICHEL, F
;
UMESONO, K
;
OZEKI, H
.
GENE,
1989, 82 (01)
:5-30

MICHEL, F
论文数: 0 引用数: 0
h-index: 0
机构:
KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN

UMESONO, K
论文数: 0 引用数: 0
h-index: 0
机构:
KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN

OZEKI, H
论文数: 0 引用数: 0
h-index: 0
机构:
KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN KYOTO UNIV,FAC SCI,DEPT BIOPHYS,KYOTO 606,JAPAN
[69]
CONSERVATION OF RNA SECONDARY STRUCTURES IN 2 INTRON FAMILIES INCLUDING MITOCHONDRIAL-ENCODED, CHLOROPLAST-ENCODED AND NUCLEAR-ENCODED MEMBERS
[J].
MICHEL, F
;
DUJON, B
.
EMBO JOURNAL,
1983, 2 (01)
:33-38

MICHEL, F
论文数: 0 引用数: 0
h-index: 0

DUJON, B
论文数: 0 引用数: 0
h-index: 0
[70]
Sensing small molecules by nascent RNA: A mechanism to control transcription in bacteria
[J].
Mironov, AS
;
Gusarov, I
;
Rafikov, R
;
Lopez, LE
;
Shatalin, K
;
Kreneva, RA
;
Perumov, DA
;
Nudler, E
.
CELL,
2002, 111 (05)
:747-756

Mironov, AS
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Gusarov, I
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Rafikov, R
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Lopez, LE
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Shatalin, K
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Kreneva, RA
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Perumov, DA
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA

Nudler, E
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA NYU, Med Ctr, Dept Biochem, New York, NY 10016 USA