Mdmx as an essential regulator of p53 activity

被引：160

作者：

Marine, JC

Jochemsen, AG ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Mol & Cell Biol, Leiden, Netherlands

[2] Flanders Interuniv, Inst Biotechnol VIB, Lab Mol Canc Biol, B-9052 Ghent, Belgium

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 331卷 / 03期

关键词：

p53; Mdmx; Mdm2; Mdm4; tumorigenesis;

D O I：

10.1016/j.bbrc.2005.03.151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine double minute 2 (Mdm2) is a critical negative regulator of the p53 tumor suppressor. Almost 10 years ago, a search for new p53-interactors revealed the existence of an Mdm2-structurally related protein, Mdmx (or Mdm4). Since then a large body of biochemical data has accumulated on the functions of Mdmx, often leading to conflicting molecular models. Nevertheless, virtually all these data pointed toward a critical role for Mdmx in the regulation of the p53-Mdm2 network. A view that was recently confirmed by genetic studies. This review is a summary of our current understanding of this molecule, its structure and biological functions, as well as its relationship to its known binding partners. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：750 / 760

页数：11

共 75 条

[1] MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice [J].