Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies?

被引：59

作者：

Cetin, I. ^{[1
]}

Huppertz, B. ^{[2
]}

Burton, G. ^{[3
,4
]}

Cuckle, H. ^{[5
,6
]}

Gonen, R. ^{[7
]}

Lapaire, O. ^{[8
,9
]}

Mandia, L. ^{[1
]}

Nicolaides, K. ^{[10
,11
]}

Redman, C. ^{[12
]}

Soothill, P. ^{[13
]}

Spencer, K.

Thilaganathan, B. ^{[14
]}

Williams, D. ^{[15
]}

Meiri, H. ^{[16
]}

机构：

[1] Univ Milan, L Sacco & Ctr Fetal Res Giorgio Pardi, Dept Clin Sci, Unit Obstet & Gynaecol, I-20157 Milan, Italy

[2] Med Univ Graz, Inst Cell Biol Histol & Embryol, Graz, Austria

[3] Univ Cambridge, Ctr Trophoblast Res, Cambridge, England

[4] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

[5] Columbia Univ, Med Ctr, New York, NY 10027 USA

[6] Univ Leeds, Leeds LS2 9JT, W Yorkshire, England

[7] Technion Israel Inst Technol, Fac Med, Bnai Zion Med Ctr, Dept Obstet & Gynecol, IL-32000 Haifa, Israel

[8] Univ Basel Hosp, Dept Biomed, Lab Prenatal Med, CH-4031 Basel, Switzerland

[9] Univ Basel Hosp, Dept Obstet & Gynaecol, CH-4031 Basel, Switzerland

[10] Kings Coll London, London WC2R 2LS, England

[11] Fetal Med Fdn, London, England

[12] John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England

[13] St Michaels Hosp, Fetal Med Unit, Bristol, Avon, England

[14] St George Hosp, Dept Obstet & Gynecol, Fetal Med Unit, London, England

[15] UCL, Inst Womens Hlth, London, England

[16] Diagnost Technol LTD, Yoqneam, Israel

来源：

PLACENTA | 2011年 / 32卷

关键词：

Preeclampsia; Placenta; Endothelial damage; Early diagnosis; IUGR; PP13; PAPP-A; PIGF; PTX3; Uterine Doppler; Genomics and proteomics markers; Surveillance; UTERINE ARTERY DOPPLER; PLACENTAL GROWTH-FACTOR; PLASMA-PROTEIN-A; TRIMESTER MATERNAL SERUM; HORMONE MESSENGER-RNA; FREE FETAL DNA; HYPERTENSIVE DISORDERS; PAPP-A; HYPERMETHYLATED RASSF1A; PREDICTING PREECLAMPSIA;

D O I：

10.1016/j.placenta.2010.11.022

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Pregenesys Consensus Meeting held in Cambridge on 13 July 2009 was organized by the Pregenesys Consortium to review and critically discuss current knowledge regarding early markers of preeclampsia, to identify priorities and opportunities for future research, to consider issues that may need to be addressed in future recommendations and to highlight key issues in cost effectiveness and national policies concerning prediction and early screening for the risk of developing preeclampsia. This report summarizes the outcome of the Consensus Meeting and draws attention to issues for further investigation with specific regard to single versus multiple markers, early versus late risk identification, and the long-term effects on both maternal and perinatal health and the need to include these in any future cost-benefit assessment. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：S4 / S16

页数：13

共 108 条

[1]

ACOG Committee on Obstetric Practice, 2002, Int J Gynaecol Obstet, V77, P67

[2] Maternal serum placental growth factor at 11+0 to 13+6 weeks of gestation in the prediction of pre-eclampsia [J].